Alternaric acid: formal synthesis and related studies

• Michael C. Slade and
• Jeffrey S. Johnson

Beilstein J. Org. Chem. 2013, 9, 166–172, doi:10.3762/bjoc.9.19

• analogue to an intermediate in a distinct formal synthetic route, and a third (unique) approach to the natural product alternaric acid. Highlighted in this study is the versatility of silyl glyoxylates to engage a variety of nucleophile and electrophile pairs to provide wide latitude in the approach to

• complex molecule synthesis. Keywords: formal synthesis; multicomponent coupling; natural products; silyl glyoxylates; Introduction The rapid development of molecular complexity from simple starting materials is an important goal in modern synthetic organic chemistry. In this context, streamlined one-pot

• transformations, cascade reactions, and multicomponent couplings have emerged as enabling tools for the synthesis of complex molecules [1][2]. Our laboratory [3][4][5][6][7][8][9][10][11][12][13][14][15][16] and others have developed [17] and employed [18][19] silyl glyoxylates 1 in a variety of synthetic